The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism
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منابع مشابه
Synthetic cannabinoid JWH-018 and psychosis: an explorative study.
BACKGROUND Aroma, Spice, K2 and Dream are examples of a class of new and increasingly popular recreational drugs. Ostensibly branded "herbal incense", they have been intentionally adulterated with synthetic cannabinoids such as JWH-018 in order to confer on them cannabimimetic psychoactive properties while circumventing drug legislation. JWH-018 is a potent cannabinoid receptor agonist. Little ...
متن کاملSelf-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
A recent study by Dr. Maria Antonietta De Luca demonstrated intravenous (IV) self-administration responding (nose-poking) for the synthetic cannabinoid JWH-018 [1-pentyl-3-(1-naphthoyl)indole] (Figure 1) in an experimentally naïve, adult rat species [1]. This finding is unexpected since the phytocannabinoid (−)-trans-Δ9tetrahydrocannabinol (Δ9-THC, Figure 1), a primary psychoactive constituent ...
متن کاملAssessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown to have abuse liability and were subsequently regulated by authorities. However, there are compounds that are still not regulated probably due to the lack of abuse liability studies. In the pres...
متن کاملConjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
K2, a synthetic cannabinoid (SC), is an emerging drug of abuse touted as "legal marijuana" and marketed to young teens and first-time drug users. Symptoms associated with K2 use include extreme agitation, syncope, tachycardia, and visual and auditory hallucinations. One major challenge to clinicians is the lack of clinical, pharmacological, and metabolic information for the detection and charac...
متن کاملData on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans
Synthetic cannabinoids JWH-018, JWH-073 and AM2201 were metabolised by the fungus Cunninghamella elegans. In this article, data on individual metabolites of their retention times, mass accuracies, major product ions and structures indicated by product ions are presented. The data in this article is related to "Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunningham...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2019
ISSN: 1567-1364
DOI: 10.1093/femsyr/foz042